Antilymphocyte/thymocyte globulin for graft versus host disease prophylaxis: efficacy and side effects
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چکیده
منابع مشابه
Post-transplant cyclophosphamide versus anti-thymocyte globulin as graft- versus-host disease prophylaxis in haploidentical transplant.
Severe graft-versus-host disease is a major barrier for non-T-cell-depleted haploidentical stem cell transplantation. There is no consensus on the optimal graft-versus-host disease prophylaxis. This study compared the two most commonly used graft-versus-host disease prophylaxis regimens (post-transplant cyclophosphamide-based vs. the anti-thymocyte globulin-based) in adults with acute myeloid l...
متن کاملTowards rational graft-versus-host disease prophylaxis.
Calcineurin inhibition for graft-versus-host disease (GvHD) prophylaxis was introduced into clinical practice of bone marrow transplantation about 35 years ago. Through the early work of Storb, Deeg and Ringden it became clear that calcineurin inhibition with cyclosporine A as a single agent was more effective than methotrexate alone and that the two drugs acted synergistically (see Table 1 for...
متن کاملChronic graft-versus-host disease: long-term results from a randomized trial on graft-versus-host disease prophylaxis with or without anti-T-cell globulin ATG-Fresenius.
Previous randomized graft-versus-host disease (GVHD)-prophylaxis trials have failed to demonstrate reduced incidence and severity of chronic GVHD (cGVHD). Here we reanalyzed and updated a randomized phase 3 trial comparing standard GVHD prophylaxis with or without pretransplantation ATG-Fresenius (ATG-F) in 201 adult patients receiving myeloablative conditioning before transplantation from unre...
متن کاملThe Role of Anti-Thymocyte Globulin or Alemtuzumab-Based Serotherapy in the Prophylaxis and Management of Graft-Versus-Host Disease
Allogeneic hematopoietic stem cell transplant is an established treatment modality for hematologic and non-hematologic diseases. However, it is associated with acute and long-term sequelae which can translate into mortality. Graft-versus-host disease (GVHD) remains a glaring obstacle, especially with the advent of reduced-intensity conditioning. Serotherapy capitalizes on antibodies which targe...
متن کاملGraft Versus Host Disease
Commonly referred to as GVHD, graft-versus-host disease is a man-made condition that arises when patients are transplanted with donor tissue that is not identical to their own. Transplants from other individuals are called allogeneic (‘allo’ meaning ‘other’ and ‘geneic’ referring to ‘genes’). GVHD occurs after hematopoietic stem cell or bone marrow transplantation but is most commonly experienc...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2004
ISSN: 0268-3369,1476-5365
DOI: 10.1038/sj.bmt.1704758